By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This booklet is the 6th quantity within the sequence Acute publicity guide degrees for Selected Airborne Chemicals, and comprises AEGLs for chemical compounds reminiscent of ammonia, nickel carbonyl and phosphine, between others.
At the request of the dept of safety, the nationwide study Council has reviewed the correct clinical literature compiled through a professional panel and tested Acute publicity guide degrees (AEGLs) for 12 new chemical compounds. AEGLs characterize publicity degrees less than which adversarial wellbeing and fitness results aren't prone to ensue and are helpful in responding to emergencies corresponding to unintentional or intentional chemical releases locally, the place of work, transportation, the army, and for the remediation of infected sites.
Three AEGLs are licensed for every chemical, representing publicity degrees that bring about: 1) extraordinary yet reversible ache; 2) long-lasting future health results; and three) life-threatening healthiness impacts.
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Extra info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6
8 h to 14 days after the start of exposure). Heart lesions were found at most exposure concentrations, but in some cases lesions were not induced regardless of the exposure scenario. Rats exposed for ≤24 h generally had mild lesions. Two rats died spontaneously, one after 4 h of exposure to 100 ppm and one after 8 h of exposure to 40 ppm; only the latter had heart lesions (a fibrinoid degenerative thrombus, a vessel change, and diffuse cellular infiltrate). It is possible that lethality would have resulted in some of these cases were the animals not killed so quickly after cessation of exposure.
SUMMARY Allylamine is a colorless or yellowish volatile liquid with a very sharp ammonia-like odor that is irritating to mucous membranes. It is highly flammable and moderately reactive with oxidizing materials. Industrially, it is used in the vulcanization of rubber and in the synthesis of pharmaceuticals. In addition to being a severe respiratory, eye, and skin irritant, allylamine is a cardiovascular toxin when administered at high doses orally, by injection, or by inhalation. Allylamine cardiotoxicity is proposed to be related to its metabolism to acrolein and hydrogen peroxide.
Air allylamine concentrations were sampled periodically, and allylamine was measured using a method designed to measure ammonia (Goldman and Jacobs 1953). No effects were seen in rats exposed to 5 ppm, with the exception of one rat that was considered an outlier (it had heart lesions, extensive abdominal tumors, hepatic abscess, and lung atelectasis). Rats exposed to 10 ppm and higher had lowered weight gain, which was correlated at 20 ppm with depletion of body fat. Rats exposed to 40 ppm became emaciated and had dull fur and, Copyright © National Academy of Sciences.
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 by National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels